3D Genomics

3D Chromatin Organization
Study the three-dimensional chromatin interactions and long-range gene regulation
3D Chromatin Organization
scGAD: single-cell gene associating domain scores for exploratory analysis of scHi-C data
Quantitative tools are needed to leverage the unprecedented resolution of single-cell high-throughput chromatin conformation (scHi-C) …
Shen S, Zheng Y++, Keleş S++
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scGAD: single-cell gene associating domain scores for exploratory analysis of scHi-C data
Normalization and De-noising of Single-cell Hi-C Data with BandNorm and scVI-3D
Single-cell high-throughput chromatin conformation capture methodologies (scHi-C) enable profiling long-range genomic interactions; …
Zheng Y+, Shen S+, Keleş S
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Normalization and De-noising of Single-cell Hi-C Data with BandNorm and scVI-3D
FreeHi-C Spike-in Simulations for Benchmarking Differential Chromatin Interaction Detection
High-throughput genome-wide chromatin conformation capture assay (Hi-C) is routinely used to profile long-range genomic interactions …
Zheng Y++, Zhou P, Keleş S++
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FreeHi-C Spike-in Simulations for Benchmarking Differential Chromatin Interaction Detection
FreeHi-C simulates high-fidelity Hi-C data for benchmarking and data augmentation
The ability to simulate high-throughput chromatin conformation (Hi-C) data is foundational for benchmarking Hi-C data analysis methods. …
Zheng Y, Keleş S
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FreeHi-C simulates high-fidelity Hi-C data for benchmarking and data augmentation
FreeHi-C simulates high-fidelity Hi-C data for benchmarking and data augmentation
The ability to simulate high-throughput chromatin conformation (Hi-C) data is foundational for benchmarking Hi-C data analysis methods. …
Ye Zheng, Sündüz Keleş
Nov 11, 2019
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FreeHi-C simulates high-fidelity Hi-C data for benchmarking and data augmentation
Three-dimensional genome architecture and disease variants
Three-dimensional genome architecture and disease variants.
Ye Zheng
Jan 19, 2019 4 min read