Epigenomics

High-throughput, high sensitivity mapping of human T cell and CAR-T cell epigenomic landscapes underscores the role of H3K27me3 in subset differences and therapeutic outcomes
Fiorenza S+, Zheng Y+, Sarthy J, Sheih AS, Wu Q, Hirayama AV, Kimble EL, Kirchmeier D, Gottardo R, Henikoff S, Turtle CJ
Code
High-throughput, high sensitivity mapping of human T cell and CAR-T cell epigenomic landscapes underscores the role of H3K27me3 in subset differences and therapeutic outcomes
CUT&Tag Data Processing and Analysis Tutorial
This tutorial is designed for processing and analyzing CUT&Tag data following the Benchtop CUT&Tag V.3 protocol. The illustration data used in this tutorial is the profiling of histone modifications in the human lymphoma K562 cell line, but the tutorial is generally applicable to any chromatin protein, including transcription factors, RNA polymerase II, and epitope-tagged proteins. For reproducible analysis, this tutorial is also available on GitHub at https://yezhengstat.github.io/CUTTag_tutorial/.
Ye Zheng
Aug 12, 2020 1 min read
CUT&Tag Data Processing and Analysis Tutorial
Discovering How Heme Controls Genome Function Through Heme-omics. Cell Reports
Protein ensembles control genome function by establishing, maintaining, and deconstructing cell-type-specific chromosomal landscapes. A …
Liao R+, Zheng Y+, Liu X, Zhang Y, Seim G, Tanimura N, Wilson G, Hematti P, Coon J, Fan J, Xu J, Keleş S++, Bresnick E++
PDF DOI
Discovering How Heme Controls Genome Function Through Heme-omics. Cell Reports