CAR-T cell therapy

High-throughput, high sensitivity mapping of human T cell and CAR-T cell epigenomic landscapes underscores the role of H3K27me3 in subset differences and therapeutic outcomes
Fiorenza S+, Zheng Y+, Sarthy J, Sheih AS, Wu Q, Hirayama AV, Kimble EL, Kirchmeier D, Gottardo R, Henikoff S, Turtle CJ
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High-throughput, high sensitivity mapping of human T cell and CAR-T cell epigenomic landscapes underscores the role of H3K27me3 in subset differences and therapeutic outcomes
Long-Term Follow-up and Single-Cell Multiomics Characteristics of Infusion Products in Patients with Chronic Lymphocytic Leukemia Treated with CD19 CAR-T Cells
Lymphodepletion chemotherapy followed by infusion of autologous T cells engineered to express a CD19-targeted chimeric antigen receptor …
Hirayama AV, Zheng Y, Dowling MR, Sheih A, Phi TD, Kirchmeier DR, Chucka AW, Gauthier J, Maloney DG, Gottardo R, Turtle CJ
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Long-Term Follow-up and Single-Cell Multiomics Characteristics of Infusion Products in Patients with Chronic Lymphocytic Leukemia Treated with CD19 CAR-T Cells